The Brasch Group

(DOI: 10.1021/acs.inorgchem.0c02968)

Synthesis and photochemical studies of 2-nitrobenzyl-caged N-hydroxysulfonamides

Zhou, Y.; Bharadwaj, V.; Rahman, M. S.; Sampson, P.; Brasch, N. E.*; Seed, A. J.* J. Photochem. Photobiol. A 2019, 384, 112033.

(DOI: 10.1016/j.jphotochem.2019.112033)

Stoichiometric Nitroxyl Photorelease Using the (6-Hydroxy-2-naphthalenyl)methyl Phototrigger

Zhou, Y.; Cink, R. B.; Seed, A. J.; Simpson,. M. C; Sampson, P.*; Brasch, N. E.* Org. Lett. 2019, 21, 1054.

(DOI: 10.1021/acs.orglett.8b04099)

Synthesis and HNO Donating Properties of the Piloty’s Acid Analogue Trifluoromethanesulphonylhydroxamic acid: Evidence for Quantitative Release of HNO at Neutral pH Conditions.

Adas, S. K; Bharadwaj, V.; Zhou, Y.; Zhang, J.; Seed, A. J.; Brasch, N. E.;* Sampson, P.* Chem. Eur. J. 2018, 24, 7330.

(DOI: 10.1002/chem.201800662)

Development of Photoactivatable Nitroxyl (HNO) Donors
Incorporating the (3-Hydroxy-2-naphthalenyl)methyl Phototrigger.

Yang Zhou, Ruth B. Cink, Zachary A. Fejedelem, M. Cather Simpson,
Alexander J. Seed, Paul Sampson,* and Nicola E. Brasch* Eur. J. Org. Chem. 2018, 1745–1755

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Rapid Photoactivated Generation of Nitroxyl (HNO) under Neutral pH Conditions.

Zhou, Y; Cink, R. B.; Dassanayake, R. S.; Seed, A. J.; Brasch, N.E.* and Sampson, P.* Angew. Chem. Int. Ed. 2016, 128, 13423–13426

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Kinetic studies on the reaction of cob(II)alamin with hypochlorous acid: Evidence for one electron oxidation of the metal center and corrin ring destruction.

Dassanayake, R. S.; Farhath, M. M.; Shelley, J. T.; Basu, S.; Brasch, N. E.* J Inorg Biochem 2016, 163, 81

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Mechanistic studies of the reactions of the reduced vitamin B₁₂ derivatives with the HNO donor Piloty’s acid: further evidence for oxidation of cob(I)alamin by (H)NO.

Subedi, H. and Brasch, N. E.* Dalton Trans., 2016, 45, 352.

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Neurobiology of Disease Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis.

Singhal, N. K.; Li, S.; Arning, E.; Alkhayer, K.; Clements, R.; Sarcyk, Z.; Dassanayake, R. S.; Brasch, N. E.; Freeman, E. J.; Bottiglieri, T. and McDonough. J.* J. Neuroscience, 2015, 35, 15170.

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Studies on the Reaction of Reduced Vitamin B₁₂ Derivatives with the Nitrosyl Hydride (HNO) Donor Angeli’s Salt: HNO Oxidizes the Transition-Metal Center of Cob(I)alamin.

Subedi, H. and Brasch, N. E.* Eur. J. Inorg. Chem., 2015, 3825.

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Pulse Radiolysis and Ultra-High Performance Liquid Chromatography/High-Resolution Mass Spectrometry Studies on the Reactions of the Carbonate Radical with Vitamin B₁₂ Derivatives.

Dassanayake, R. S.; Shelley, J. T.; Cabelli, D. E.* and Brasch, N. E.* Chem – Eur. J., 2015, 21, 6409. (Article featured on the inside journal cover and classified as a “Hot Paper.”)

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Pulse Radiolysis Studies of the Reaction of Nitrogen Dioxide with the Vitamin B₁₂ Complexes Cob(II)alamin and Nitrocobalamin.

Dassanayake, R. S.; Cabelli, D. E. and Brasch, N. E.* J. Inorg. Biochem., 2015, 142, 54.

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Kinetic and Mechanistic Studies on the Reaction of the Vitamin B₁₂ Complex Aquacobalamin with the HNO Donor Angeli’s Salt: Angeli’s Salt and HNO React with Aquacobalamin.

Subedi, H.; Hassanin, H. A. and Brasch, N. E.* Inorg. Chem., 2014, 53, 1570.

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Mechanistic Studies on the Reaction of Nitroxylcobalamin with Dioxygen: Evidence for Formation of a Peroxynitritocob(III)alamin Intermediate.

Subedi, H. and Brasch, N. E.* Inorg. Chem., 2013, 52, 11608.

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Pulse Radiolysis Studies on the Reaction of the Reduced Vitamin B₁₂ Complex Cob(II)alamin with Superoxide.

Dassanayake, R. S.; Cabelli, D. E.* and Brasch, N. E.*, ChemBioChem., 2013, 14, 1081.

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Mechanistic Studies on the Reaction of Nitrocobalamin with Glutathione: Kinetic Evidence for Formation of an Aquacobalamin Intermediate.

Walker, D. T.; Dassanayake, R. S.; Garcia, K. A.; Mukherjee, R.; and Brasch, N. E.*, Europ. J. Inorg. Chem. 2013, 3049.

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The Effects of Ligand Decomposition on the Pseudo-First Order Profile of a Ligand Substitution Reaction: A “silent killer” in the background.

Conrad, A. R.; Hassanin, H. A.; Tubergen, M. J.; Fàbiàn, I. and Brasch, N. E.*, New J. Chem. 2012, 36, 1408.

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Kinetic and Mechanistic Studies on the Reactions of the Reduced Vitamin B₁₂ Complex Cob(I)alamin with Nitrite and Nitrate.

Plymale, N. T.; Dassanayake, R. S.; Hassanin, H. A. and Brasch, N. E.*, Europ. J. Inorg. Chem. 2012, 913. (Article featured on the journal cover.)

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Kinetic Studies on the Reaction between Cob(I)alamin and Peroxynitrite: Rapid Oxidation of Cob(I)alamin to Cob(II)alamin by Peroxynitrous Acid.

Mukherjee, R. and Brasch, N. E.*, Chem. – Eur. J., 2011, 17, 11723-11727, DOI: 10.1002/chem.201102267. (Article featured on the journal cover.)

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Mechanistic Studies on the Reaction between Cob(II)alamin and Peroxynitrite: Evidence for a Dual Role for Cob(II)alamin as a Scavenger of Peroxynitrous Acid and Nitrogen Dioxide.

Mukherjee, R. and Brasch, N. E.*, Chem. – Eur. J., 2011, 17, 11805-11812; DOI: 10.1002/chem.201100223. (Article featured on the journal cover.)

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Kinetic Studies on the Decomposition of Thiolatocobalamins in Acidic Solution.

Schumacher, L. A.; Mukherjee, R.; Brown, J. M.; Subedi, H. and Brasch, N. E.*, Eur. J Inorg. Chem., 2011, 4717; DOI: 10.1002/ejic.201100246.

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Vitamin B₁₂ protects against superoxide-induced cell injury in human aortic endothelial cells.

Moreira, E. S.; Brasch, N. E. and Yun, J.*, Free Radic. Biol. Med. 2011, 11, 876.

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Redetermination of the X-ray Structure of Nitroxylcobalamin: Base-on Nitroxylcobalamin exhibits a remarkably long Co-N(dimethylbenzimidazole) bond distance

Hassanin, H. A.; El-Shahat, M. F.; DeBeer, S.; Smith, C. A.* and Brasch, N. E.*, Dalton Trans. 2010, 10626.

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Self-assembly of a two-dimensional barium/thiodiacetate coordination polymer in aqueous solution.

Mukherjee, R.; Bunge, S. D. and Brasch, N. E.*, Contribution to a Special Issue dedicated to Professor R. van Eldik in J. Coord. Chem., 2010, 63, 2821.

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Vitamin B₁₂ and redox homeostasis: Cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD)

Suarez-Moreira, E.; Yun, J.; Birch, C. S.; Williams, J. H. H.; McCaddon, A.; Brasch, N. E.*, J. Am. Chem. Soc, 2009, 131(42), 15078.

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Mechanistic Studies on the Reaction between R₂N-NONOates and Aquacobalamin: Evidence for Direct Transfer of a Nitroxyl (NO^–) Group from R₂N-NONOates to Cobalt(III) Centers

Hassanin, H. A.; Hannibal, L.; Jacobsen, D. W.; El-Shahat, M. F.; Hamza, M. S. A and Brasch, N. E.*, Angew. Chemie Int. Ed., 2009, 48(47), 8909.

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Synthesis, Synchrotron X-ray Diffraction and Kinetic Studies on the Formation of a Novel Thiolatocobalamin of Captopril: Evidence for cis-trans isomerization in the ?-axial Ligand

Mukherjee, R.; McCaddon, A.; Smith, C. A.; Brasch, N. E.*, Inorg. Chem., 2009, 48(19), 9526.

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High Resolution Crystal Structure Determination of the Methylcobalamin Analogs Ethylcobalamin and Butylcobalamin by X-ray Synchrotron Diffraction

Hannibal. L.; Smith, C. A.; Smith, J. A.; Axhemi, A.; Miller,A.; Wang, S.; Brasch, N. E. and Jacobsen, D. W.*, Inorg. Chem., 2009, 48(14), 6615.

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A novel role for vitamin B₁₂: Cobalamins are intracellular antioxidants in vitro

Birch, C. S.; Brasch, N. E.; McCaddon, A. and Williams, J. H. H.*, Free Radical Biol. Med., 2009, 47(2), 184.

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Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product

Hannibal, L.; Kim, J.; Brasch, N. E.; Wange, S.; Rosenblatt, D. S.; Banerjee, R.; Jacobsen, D. W.* Mol. Gen. Metab. 2009, 97, 260.

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NMR Spectroscopy and Molecular Modelling Studies of Nitrosylcobalamin: Further Evidence that the Deprotonated, Base-off Conformation is an Important Conformation of Nitrosylcobalamin in Solution

Hassanin, H. A.; Hannibal, L.; Jacobsen, D. W.; Brown, K. L.; Marques, H. L.* and Brasch, N. E.*, Dalton Trans. 2009, 424 (selected for the journal cover and selected as a “Hot Article”).

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Accurate Assessment and Identification of Naturally Occurring Cellular Cobalamins

Hannibal, L.; Axhemi, A.; Glushchenko, A. V.; Suarez-Moreira, E.; Brasch, N. E.*; Jacobsen, D. W.*, Clin. Chem. Lab. Med. 2008, 46, 1739.

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Vanadium-Vitamin B₁₂ Bioconjugates as Potential Therapeutics for Treating Diabetes

Mukherjee, R.; Donnay, E. G.; Radomski, M. A.; Miller, C.; Redfern, D. A.; Gericke, A.; Damron, D. S.; Brasch, N. E.* Chem. Commun. 2008, 3783.

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Synthesis and X-ray structural characterization of tris(L-glycinato)vanadium(III) and trans-tetraquadichlorovanadium(III) chloride

Fry, F. H.;* Dougan, B.; McCann, N.; Willis, A. C.; Ziegler, C. J.; Brasch, N. E.* Inorg. Chim. Acta 2008, 2321.

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Nitroxylcob(III)alamin: Synthesis and X-ray Structural Characterization

Hannibal, L.; Smith, C. A.; Jacobsen, D. W.; Brasch, N. E.* Angew. Chem. 2007, 46, 5140.

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X-ray Structural Characterization of Imidazolylcobalamin and Histidinylcobalamin: Cobalamin Models for Aquacobalamin Bound to the B₁₂ Transporter Protein Transcobalamin

Hannibal, L.; Bunge, S. D.; van Eldik, R.; Jacobsen, D. W.; Kratky, C.; Gruber, K.;* Brasch, N. E.* Inorg. Chem. 2007, 46, 3613.

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Structural and Spectroscopic Evidence for Formation of Trinuclear and Tetranuclear V(III)/Carboxylate Complexes of Acetate and Related Derivatives in Aqueous Solution

Mukherjee, R.; Dougan, B. A.; Fry, F. H.; Bunge, S. D.; Ziegler, C. J.; Brasch, N. E.* Inorg. Chem. 2007, 46, 1575.

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A Simple, Convenient Method to Synthesize Cobalamins: Synthesis of Homocysteinylcobalamin, N-Acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, Sulfitocobalamin and Nitrocobalamin

Suarez-Moreira, E.; Hannibal, L.; Smith, C. A.; Chavez, R. A.; Jacobsen, D. W. and Brasch, N. E.* Dalton Trans. 2006, 5269.

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Characterization of Novel Vanadium(III)/Acetate Clusters Formed in Aqueous Solution

Fry, F. H.; Dougan, B. A.; McCann, N.; Ziegler, C. J.; Brasch, N. E.* Inorg. Chem. 2005, 44, 5197.

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Ligand Exchange on Phosphenium Ions: Reversible Exchange between Free and Coordinated Alkynes in Phosphirenium Salts

Brasch, N. E.;* Hamilton, I. G.; Krenske, E. H.; Wild, S. B.*Organomet. 2004, 23, 299.

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Studies on the Formation of Glutathionylcobalamin: Any Free Intracellular Aquacobalamin is Likely to be Rapidly and Irreversibly Converted to Glutathionylcobalamin

Xia, L.; Cregan, A. G.; Berben, L. A.; Brasch, N. E.* Inorg. Chem. 2004, 43, 6848.

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Method of synthesis of ?-thiolato cobalamin nucleoside compounds

Brasch, N. E.*; Xia, L., U.S. Patent Appl. 20040054128, 2004.

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A Novel Redox Mechanism for the Glutathione-dependent Reversible Uptake of a Fungal Toxin in Cells

Bernado, P. H.; Brasch, N.; Chai, C. L. L.; Waring, P.*J. Biol. Chem.2003, 278, 46549.

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The Reaction Between Methylcobalamin and Cyanide Revisited

Brodie, S. F.; Cregan, A. G.; van Eldik, R.; Brasch, N. E.* Inorg. Chim. Acta 2003, 348, 221.

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Mechanistic Insight from Activation Parameters for the Reaction between Coenzyme B₁₂ and Cyanide: Further Evidence that Heterolytic Co-C Bond Cleavage is Solvent-Assisted

Hamza, M. S. A.; Cregan, A. G.; Brasch, N. E.*; van Eldik, R.* Dalton Trans. 2003, 596.

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Studies on the Mechanism of the Reaction between 5′-Deoxyadenosylcobinamide and Cyanide

Brasch, N. E.*; Cregan, A. G.; Vanselow, M. L. Dalton Trans. 2002, 1287.

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Synthesis, Characterization, Solution Stability and X-ray Crystal Structure of the Thiolatocobalamin ?-Glutamylcysteinylcobalamin, a Dipeptide Analog of Glutathionylcobalamin: Insights Into the Enhanced Co-S Bond Stability of the Natural Product Glutathionylcobalamin

Suto, R. K.; Brasch, N. E.; Anderson, O. P.; Finke, R. G.* Inorg. Chem. 2001, 40, 2686.

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Thermodynamic and Kinetic Studies on the Reaction between the Vitamin B₁₂ Derivative ?-(N-Methylimidazolyl)cobalamin and N-Methylimidazole: Ligand Displacement at the ? Axial Site of Cobalamins

Cregan, A. G.; Brasch, N. E.;* van Eldik, R.* Inorg. Chem. 2001, 40, 1430.

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Studies on the Mechanism of the Reaction Between Coenzyme B₁₂ and Cyanide: Direct ¹H NMR Spectroscopic Evidence for a (?-5′-Deoxyadenosyl)(?-cyano)cobalamin Intermediate

Brasch, N. E.;* Haupt, R. J. Inorg. Chem. 2000, 39, 5469.

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A Simple, Convenient and Direct Method for Assessing the Purity of Cobalamins

Brasch, N. E.; Finke, R. G.*J. Inorg. Biochem. 1999, 73, 215.

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Synthesis and Characterization of Isolable Thiolatocobalamin Complexes Relevant to Coenzyme B₁₂-Dependent Ribonucleotide Triphosphate Reductase

Brasch, N. E.; Hsu, T.-L. C.; Doll, K.; Finke, R. G.* J. Inorg. Biochem. 1999, 76, 197.

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The Second Isolable B₁₂-Thiolate Complex, (Pentafluorophenylthiolato)cobalamin: Synthesis and Characterization

Hsu, T.-L. C.; Brasch, N. E.; Finke, R. G.* Inorg. Chem. 1998, 37, 5109.

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¹⁷O NMR Study of Solvent Exchange in Some Aqueous [Co(tren)(X)(OH₂/OH)]ⁿ⁺, [Co(cyclen)(X)(OH₂/-OH)] ⁿ⁺, and [Co(N-Mecyclen)(X)(OH₂/OH)ⁿ⁺ Systems (X = NH₃, OH₂/OH; n = 3, 2, 1)

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R.; Rogers, A. J. Inorg. Chem. 1998, 37, 4865.

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Formation of an Association Complex between Methylcobalamin and Cyanide

Brasch, N. E.; Mueller, F.; Zahl, A.; van Eldik, R.* Inorg. Chem. 1997, 36, 4891.

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Evidence for the Unexpected Associative Displacement of Adenosyl by Cyanide in Coenzyme B₁₂

Brasch, N. E.; Hamza, M. S. A.; van Eldik, R.* Inorg. Chem. 1997, 36, 3216.

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Nucleophilic Catalysis by HPO₄^2- in the Hydrolysis of Cr₂O₇^2-. Formation and Decay of HO₃POCrO₃^2-

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R. Aust. J. Chem. 1994, 47, 2283.

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Hydrolysis of Cr₂O₇^2-. Nucleophilic Catalysis by TRIS and Rate Laws for the Formation and Decay of a (TRIS)CrO₃ Intermediate

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R. Inorg. Chem. 1994, 33, 2683.

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Orthophosphate Complexes of Cobalt(III), trans-[Co(en)₂(OH₂)(OPO₃H)]ClO₄10.5H₂O and its Properties in Aqueous Solution

Brasch, N. E.; Buckingham, D. A.*; Simpson, J.; Stewart, I. Inorg. Chem. 1990, 29, 371.

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4. Origin of the Products in the Base Hydrolysis of [Co(NH₃)₅X]^(3-n)+ Complexes

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R.; Finnie, K. S. Inorg. Chem. 1989, 28, 4567.

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Stereochemical Change in the Hg²⁺-, Ag⁺-, and Cl₂-Induced and Spontaneous Reactions of Pentaamminecobalt-(III)-Acido Species: A Reexamination

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R.; Finnie, K. S. Inorg. Chem. 1989, 28, 3386.

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In Memoriam Aaron Swartz